Radboudumc
ESR 2 fellow
Work package 2 and 5
Biomaterials
•
Elastin
•
Extracellular matrix
•
Skin regeneration
Background
Roman was born in Severodonetsk (Luhansk region, Ukraine). He obtained his bachelor and first master degree in Organic Chemistry at Taras Shevchenko National University of Kyiv, Ukraine. He also successfully accomplished a second master degree in Belgium/Italy; the European Master on Translational Cosmetic and Dermatological Sciences (EMOTION). In 2018 he spent one semester at Uppsala University (Sweden) with an Erasmus+ Exchange Mobility Program. He gained work experience through a 4-year internship in organic synthesis at Enamine Ltd.
PhD project: Identification and application of specific elastin hydrolysates for scarless skin regeneration
Roman is a PhD candidate at Radboud university medical center, the Netherlands. His research focuses on elastin, a largely neglected extracellular matrix protein, with attractive biological and biomechanical characteristics that may be used to develop biomaterials for scarless skin regeneration. Effective elastin preparations are crude fractions derived from mature elastic fibres that may improve skin wound healing. In this project, fractionated elastin preparations are being studied. The availability of such preparations may lead to improved skin substitutes for wound healing.
Roman visits three partners during his PhD study to achieve the objectives below; at the Association of Dutch Burn Centers, Beverwijk, the Netherlands, at the University of Zürich, Switzerland and at MedSkin Solutions Dr. Suwelack AG, Billerbeck, Germany.
Objectives
- Preparation and characterisation of defined elastin hydrolysates.
- In vitro evaluation of fractionated elastin hydrolysates.
- In vivo analysis of scaffolds containing fractionated elastin hydrolysates for scarless skin regeneration.